Fertility

Peptides for Male Fertility: Kisspeptin, NAD+, and Protecting Your Sperm

June 20, 2026 11 min read PowerPeptides Research

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If you’re trying to conceive, your peptide choices matter. Some peptides support male fertility through hormonal signaling and cellular quality. Others — particularly GLP-1 agonists and anything that suppresses the HPG axis — should be discontinued. Here’s the evidence-based breakdown.

Fertility-Supporting Peptides

Kisspeptin-10 — Restore LH Pulsing

Kisspeptin-10 is the master regulator of reproductive hormone signaling. It triggers GnRH release, which drives LH and FSH — the hormones that stimulate testosterone production and spermatogenesis in the testes. Published human studies show kisspeptin increases LH pulsing in men, directly supporting the hormonal cascade required for sperm production.

For men with secondary hypogonadism (low T from poor signaling rather than testicular failure), kisspeptin addresses the actual problem rather than masking it with exogenous testosterone.

NAD+ — Sperm Mitochondrial Function

Sperm cells are among the most metabolically active cells in the body. Their motility depends on mitochondrial ATP production. NAD+ supports mitochondrial electron transport chain function, potentially improving sperm motility and reducing oxidative damage to sperm DNA.

What to Avoid When Trying to Conceive

Compound	Impact on Fertility	Recommendation
Exogenous testosterone (TRT)	Severely suppresses spermatogenesis	Discontinue 3-6 months before conception attempt. Switch to HCG or kisspeptin.
Semaglutide / GLP-1 agonists	Animal data shows potential reproductive effects	Discontinue 2+ months before conception attempt per FDA labeling.
SARMs	Suppress HPTA, reduce sperm count	Discontinue 3+ months before. Full PCT required.
Finasteride	Can reduce sperm count and volume	Discontinue. Recovery takes 3-6 months.

Fertility-Compatible Peptides

These peptides have no known negative impact on male fertility:

BPC-157: No interaction with reproductive axis
GHK-Cu: No hormonal interaction
Semax/Selank: No reproductive effects documented
CJC-1295/Ipamorelin: GH secretagogues don’t suppress reproductive hormones

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Frequently Asked Questions

Can peptides improve sperm quality?

Kisspeptin-10 supports the hormonal cascade required for spermatogenesis. NAD+ supports sperm mitochondrial function and motility. These may improve sperm parameters in men with hormonal or metabolic-driven fertility issues.

Should I stop TRT when trying to conceive?

Yes. Exogenous testosterone severely suppresses spermatogenesis. Discontinue 3-6 months before attempting conception. Switch to HCG or kisspeptin to maintain testosterone levels while allowing sperm production to recover.

Does semaglutide affect male fertility?

FDA labeling recommends discontinuing semaglutide 2+ months before planned conception due to animal data showing potential reproductive effects. Human fertility data is limited.

Is BPC-157 safe while trying to conceive?

BPC-157 does not interact with the reproductive axis and has no documented impact on male fertility. It is considered fertility-compatible for men trying to conceive.

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