PCT Protocol

PCT Peptides: Recovery Protocol After SARMs or AAS

June 20, 2026 11 min read PowerPeptides Research

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You ran a cycle. Now your HPTA is suppressed, your LH is in the basement, and your body has temporarily forgotten how to make testosterone on its own. Traditional PCT relies on SERMs (Clomid, Nolvadex) to kickstart recovery. But SERMs come with their own side effects: mood disturbances, visual disturbances (Clomid), and they block estrogen receptors rather than restoring the full hormonal cascade from the top down.

Peptide-based PCT takes a different approach: restart the signaling cascade from the hypothalamus, support organ recovery, and restore sleep architecture while your HPTA comes back online.

The Peptide PCT Stack

Kisspeptin-10 — Restart LH Pulsing

Kisspeptin-10 is the master trigger of the HPG axis. It stimulates GnRH neurons in the hypothalamus, which triggers LH and FSH release from the pituitary, which signals the testes to produce testosterone. Where SERMs block estrogen receptors to trick the brain, kisspeptin directly activates the upstream signal. Published human data shows kisspeptin-54 robustly increases LH pulsing in men.

BPC-157 — Organ Protection

Oral compounds (SARMs, orals) stress the liver. Injectable cycles may stress the kidneys. BPC-157 has documented cytoprotective effects on the liver, kidneys, and GI tract. During PCT, when your body is recovering from exogenous compounds, organ protection is critical.

NAD+ — Cellular Recovery

Cycles deplete NAD+ through increased oxidative stress and metabolic demands. NAD+ supplementation during PCT supports mitochondrial function and cellular repair at the foundation level.

DSIP — Sleep Architecture

Post-cycle cortisol is often elevated while testosterone is suppressed — the worst hormonal ratio for sleep, mood, and recovery. DSIP enhances delta wave (deep) sleep, which is when GH is released and tissue repair occurs. Fixing sleep during PCT accelerates hormonal recovery.

PCT Protocol Timeline

Week	Kisspeptin-10	BPC-157	NAD+	DSIP
1-2	100-200mcg 2x/day	250-500mcg/day	100-200mg 3x/week	100-200mcg nightly
3-4	100-200mcg daily	250mcg/day	100mg 3x/week	As needed
5-6	100mcg every other day	Taper off	Taper off	As needed

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Frequently Asked Questions

Can I use peptides for PCT instead of Clomid?

Kisspeptin-10 restarts LH pulsing from the hypothalamic level, which is upstream of where SERMs work. It may be used alongside or instead of traditional SERMs. However, kisspeptin PCT protocols are less established than SERM protocols. Bloodwork (LH, FSH, Total/Free T) is essential to monitor recovery.

Does kisspeptin raise testosterone?

Yes. Kisspeptin directly stimulates GnRH release, triggering the LH/FSH cascade that drives testicular testosterone production. Human studies show kisspeptin-54 increases LH pulsing in healthy men. It restores natural production rather than replacing it.

How long does peptide PCT take?

A typical peptide PCT runs 4-6 weeks, similar to SERM PCT. Bloodwork at weeks 4 and 8 (after completing PCT) confirms recovery. Full HPTA restoration depends on cycle length, compounds used, and individual response.

Is BPC-157 necessary during PCT?

BPC-157 provides organ protection during the recovery period. If you ran oral compounds (which stress the liver) or experienced GI issues during cycle, BPC-157’s cytoprotective effects are particularly relevant.

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